01664nas a2200181   4500008004100000245005100041210005100092260000800143300000900151490000600160520115500166100001501321700001701336700001601353700001901369700001401388856008001402       2016                        eng d00aFate of inorganic nanoparticles in agriculture0 aFate of inorganic nanoparticles in agriculture  cJAN  a3-120 v73 a<p>In modern world, engineered nanoparticles (ENPs) are increasingly becoming an important component of daily life. They are becoming an integral part of a wide range of man-made products including electronics, paints, biomedical products, sunscreens, clothing, automobiles, etc. Rapid progress in the manufacturing of ENPs and the subsequent increase in its commercial applications always have had an impact on agriculture due to the exposure of living things to these ENPs. Also, human beings are directly dependent on the plants because of their nutritional values. Hence, the impact of nanoparticles on agricultural soil and plants is always of topical interest. It is imperative to be aware of the effects of nanoparticles on soil as well as on the soil ecosystem it supports especially the soil microbes and plants; or more specifically whether they have an influence on the agricultural yield and agri-economy. It is also important to study the effects of man-made nanomaterials on the properties of agricultural soil. This work reviews some of the key features of the impact of ENPs on the environment and the fate of ENPs in agriculture.</p>1 aPhogat, N.1 aKhan, S., A.1 aShankar, S.1 aAnsary, A., A.1 aUddin, I.  uhttps://library.ncl.res.in/content/fate-inorganic-nanoparticles-agriculture02946nas a2200337   4500008004100000245008600041210006900127260000800196300001200204490000800216520197300224653001002197653001702207653001302224653001702237653002202254653002902276653000902305653002202314653002302336100001302359700001502372700001302387700001302400700001302413700001902426700001402445700002002459700001502479856011402494       2017                        eng d00aGold nanoconjugates reinforce the potency of conjugated cisplatin and doxorubicin0 aGold nanoconjugates reinforce the potency of conjugated cisplati  cDEC  a254-2640 v1603 aOsteosarcoma or osteogenic sarcoma is the most common and prevalent cancerous tumor of bone and occurs especially in children and teens. Recent treatment strategy includes a combination of both chemotherapy and surgeries. Although, the use of single drug-based chemotherapy treatment remains unsatisfactory. Therefore, combinatorial therapy has emerged as a potential strategy for treatment with limited side- effects. Here, we evaluated the combinatorial anticancerous effect of cisplatin (CIS) and doxorubicin (DOX) bioconjugated bromelain encapsulated gold nanoparticles (B-AuNPs conjugated CIS and DOX) in the treatment of osteosarcoma. The synthesized B-AuNPs conjugated CIS and DOX were characterized by various characterization techniques like UV–vis spectroscopy, TEM, DLS and zeta potential to ensure the synthesis, size, shape, size distribution and stability. Drug loading efficiency bioconjugation of CIS and DOX was ensured by UV–vis spectroscopy. Bioconjugation of CIS and DOX was further confirmed using UV–vis spectroscopy, TEM, DLS, Zeta potential and FT-IR analysis. The combinatorial effect of CIS and DOX in B-AuNPs conjugated CIS and DOX showed highly improved potency against MG-63 and Saos-2 cells at a very low concentration where primary osteoblasts didn't show any cytotoxic effect. The apoptotic effect of B-AuNPs conjugated CIS and DOX on osteosarcoma and primary osteoblasts cells were analyzed by increased permeability of the cell membrane, condensed chromatin and deep blue fluorescent condensed nucleus. The results clearly showed that B-AuNPs conjugated CIS and DOX significantly improved the potency of both the chemotherapeutic drugs by delivering them specifically into the nucleus of cancer cells through caveolae-dependent endocytosis. Thus, the greater inhibitory effect of combinatorial drugs (B-AuNPs conjugated CIS and DOX) over single drug based chemotherapy would be of great advantage during osteosarcoma treatment. 10acells10achemotherapy10aCytology10aCytotoxicity10aDrug interactions10adynamic light scattering10aGold10aMolecular Biology10aPlatinum Compounds1 aIram, S.1 aZahera, M.1 aKhan, S.1 aKhan, I.1 aSyed, A.1 aAnsary, A., A.1 aAmeen, F.1 aShair, O., H. M1 aKhan, M.S.  uhttps://library.ncl.res.in/content/gold-nanoconjugates-reinforce-potency-conjugated-cisplatin-and-doxorubicin