02069nas a2200241   4500008004100000245009300041210006900134260000800203300001600211490000600227520124200233100002401475700002701499700002301526700002301549700002201572700002101594700002901615700002101644700001601665700002201681856012401703       2017                        eng d00aNIR light-triggered shrinkable thermoresponsive PNVCL nanoshells for cancer theranostics0 aNIR lighttriggered shrinkable thermoresponsive PNVCL nanoshells   cSEP  a44026-440340 v73 aFor the localized treatment of a tumor in a more controlled fashion, several stimuli-responsive nanocarriers and minimally or non-invasive techniques like photothermal therapy (PTT) have emerged. However, PTT is limited to only treatment of small and superficial tumors due to the inability of NIR light to penetrate more and kill the core cells of large and deep-seated tumors. As a preliminary step towards addressing the problem, NIR light-triggered thermoresponsive theranostic nanoshell consisting of chitosan-grafted poly(N-vinyl caprolactam) as core and biocompatible gold as shell (Au PNVCL NS) are synthesized and well characterized by various techniques. PNVCL is polymerized from N-vinyl caprolactam using free radical polymerization method, and chitosan is grafted to raise its lower critical solution temperature (LCST) to hyperthermic temperature (∼43 °C). Surface plasmon resonant gold shell over PNVCL NPs core is assembled by ascorbic acid-driven in situ reduction. Core to shell diameter ratio is controlled to tune the peak in NIR region (750 nm). Therapeutic potential of Au PNVCL NS is determined over breast cancer cells MCF-7, while diagnostic potential is compared with the commercial contrast agent-Omnipaque.1 aChauhan, Deepak, S.1 aSingaravelu, Indulekha1 aGottipalli, Rupesh1 aReddy, Pradeep, K.1 aChikate, Tanmayee1 aGupta, Ramkrishn1 aJahagirdar, Dushyant, N.1 aPrasad, Rajendra1 aDe, Abhijit1 aSrivastava, Rohit  uhttps://library.ncl.res.in/content/nir-light-triggered-shrinkable-thermoresponsive-pnvcl-nanoshells-cancer-theranostics