01592nas a2200145   4500008004100000245011000041210006900151260000800220300001400228490000700242520102400249100002001273700002301293856013001316       2017                        eng d00aAutomating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic0 aAutomating multistep flow synthesis approach and challenges in i  cAPR  a960–9870 v133 aThe implementation of automation in the multistep flow synthesis is essential for transforming laboratory-scale chemistry into a reliable industrial process. In this review, we briefly introduce the role of automation based on its application in synthesis viz. auto sampling and inline monitoring, optimization and process control. Subsequently, we have critically reviewed a few multistep flow synthesis and suggested a possible control strategy to be implemented so that it helps to reliably transfer the laboratory-scale synthesis strategy to a pilot scale at its optimum conditions. Due to the vast literature in multistep synthesis, we have classified the literature and have identified the case studies based on few criteria viz. type of reaction, heating methods, processes involving in-line separation units, telescopic synthesis, processes involving in-line quenching and process with the smallest time scale of operation. This classification will cover the broader range in the multistep synthesis literature.1 aShukla, Chinmay1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/automating-multistep-flow-synthesis-approach-and-challenges-integrating-chemistry-machines