02041nas a2200253   4500008004100000022001400041245006600055210006600121260000900187490000700196520129900203653001401502653001401516653001801530653001801548653001901566100001701585700001901602700002101621700001501642700001701657700001901674856009401693       2024                        eng d  a0947-653900aLanthanide mimicking by magnesium for oxazolidinone synthesis0 aLanthanide mimicking by magnesium for oxazolidinone synthesis  cJAN 0 v303 a<p>In the last decade, magnesium complexes have emerged as a viable alternative to transition-metal catalysts for the hydrofunctionalization of unsaturated bonds. However, their potential for advanced catalytic reactions has not been thoroughly investigated. To address this gap, we have developed a novel magnesium amide compound (3) using a PNP framework that is both bulky and flexible. Our research demonstrates that compound 3 can effectively catalyze the synthesis of biologically significant oxazolidinone derivatives. This synthesis involves a tandem reaction of hydroalkoxylation and cyclohydroamination of isocyanate using propargyl alcohol. Furthermore, we conducted comprehensive theoretical calculations to gain insights into the reaction mechanism. It is important to note that these types of transformations have not been reported for magnesium and would significantly enhance the catalytic portfolio of the 7th most abundant element. A monomeric magnesium compound was employed as a catalyst for the cascade cyclization of propargylic alcohol and isocyanate, resulting in the formation of pharmaceutically significant oxazolidinone derivatives. This transformation, previously attributed solely to transition metals or lanthanides, signifies a noteworthy advancement.image</p>
10acatalysis10aMagnesium10aoxazolidinone10apincer ligand10aSustainability1 aKumar, Rohit1 aMahata, Biplab1 aGayathridevi, S.1 aRaj, Vipin1 aVanka, Kumar1 aSen, Sakya, S.  uhttps://library.ncl.res.in/content/lanthanide-mimicking-magnesium-oxazolidinone-synthesis