00686nas a2200181 4500008004100000022001400041245006200055210006200117260000800179300000900187490000700196653012600203100002400329700001800353700001900371700002000390856009400410 2014 eng d a2053-273300aSupramolecular synthon hierarchy in bumetanide cocrystals0 aSupramolecular synthon hierarchy in bumetanide cocrystals cFEB aC7210 v7010aNovel cocrystals of sulfonamide drug Bumetanide with carboxamides are developed based on supramolecular synthons approach1 aAllu, Suryanarayana1 aBolla, Geetha1 aTothadi, Srinu1 aNangia, Ashwini uhttps://library.ncl.res.in/content/supramolecular-synthon-hierarchy-bumetanide-cocrystals01861nas a2200169 4500008004100000245007400041210006900115260000800184300001400192490000700206520129100213100002401504700001801528700001901546700002001565856010601585 2017 eng d00aSupramolecular synthons in bumetanide cocrystals and ternary products0 aSupramolecular synthons in bumetanide cocrystals and ternary pro cAUG a4225-42360 v173 aA novel design strategy for cocrystals of the diuretic sulfonamide drug bumetanide (BUM) with carboxamides is reported based on reliable supramolecular synthons. Binary cocrystals of BUM with pyridine carboxamides, pyridones, and cytosine were obtained by solvent assisted grinding followed by solution crystallization. All cocrystal structures exhibit hydrogen bonding of the coformer with the carboxylic acid group of BUM via heterosynthons which replace the acid homodimer in the drug crystal structure. Pyridones are inserted as N-H center dot center dot center dot O dimers which are in turn bonded to the acid group of BUM, while the pyridine amide coformers interact via the acid amide heterosynthon. Cocrystal polymorphs were obtained for bumetanide isonicotinamide cocrystal structure with the sulfonamide pyridine and sulfonamide acid synthons. Careful crystal packing analysis of BUM structure and nine new binary adducts gave an idea for the design ternary cocrystals, and subsequently four new ternary crystalline products were crystallized. Whereas the binary cocrystal structures were confirmed by single crystal diffraction, the ternary combinations were chatacterized by their unique powder X-ray diffraction patterns as well as by thermal and spectroscopic techniques.1 aAllu, Suryanarayana1 aBolla, Geetha1 aTothadi, Srinu1 aNangia, Ashwini uhttps://library.ncl.res.in/content/supramolecular-synthons-bumetanide-cocrystals-and-ternary-products01117nas a2200169 4500008004100000022001400041245009200055210006900147260000900216300001400225490000700239520051600246100001900762700002400781700002400805856011800829 2020 eng d a1528-748300aSalts and cocrystal of etodolac: advantage of solubility, dissolution, and permeability0 aSalts and cocrystal of etodolac advantage of solubility dissolut cJUL  a4512-45220 v203 a

{Etodolac (ETD) is a nonsteroidal anti-inflammatory drug (NSAID) approved by the United States Food and Drug Administration (US-FDA) in 1991 for the treatment of rheumatoid arthritis. Because of its poor aqueous solubility and high permeability, ETD falls under Biopharmaceutics Classification System (BCS) Class II drug. The present study was aimed to screen stable salts and cocrystals of ETD using Generally Recognized as Safe (GRAS) and a few non-GRAS coformers. Crystallization of five salts (i.e.

1 aRai, Sunil, K.1 aAllu, Suryanarayana1 aNangia, Ashwini, K. uhttps://library.ncl.res.in/content/salts-and-cocrystal-etodolac-advantage-solubility-dissolution-and-permeability02461nas a2200169 4500008004100000245011900041210006900160260000800229300001600237490000700253520180700260100002402067700001902091700002902110700002402139856012802163 2022 eng d00aSynthesis of ternary cocrystals, salts, and hydrates of acefylline with enhanced dissolution and high permeability0 aSynthesis of ternary cocrystals salts and hydrates of acefylline cJUN a4165–41810 v223 a

Acefylline (ACF) is a stimulant xanthine derivative drug, which is formulated as a piperazine salt for the treatment of bronchial asthma. ACF falls under BCS class IV category of low solubility and poor permeability, which together limit the bioavailability and efficacy of the drug. In this work, ACF binary and ternary cocrystals, salts–cocrystals, and their polymorphs are synthesized by cocrystallization with several coformers. Two different methods were adopted for the supramolecular assembly of the ternary systems A.B.C: (1) first, binary adducts A.B or A.C were crystallized by grinding a slurry of the components in a suitable solvent and then C was added and grinding was continued; and (2) all three components were taken in a solvent slurry and ground together. The former method was found to be superior in affording the ternary salt/cocrystal. The role of laboratory seeding is implicated to explain the variation in crystallization results at different stages of the project. Crystal structures of the product’s binary and ternary systems were solved by single-crystal X-ray diffraction and powder X-ray diffraction data for structure solution. The crystal structures show the recurrence of carboxylate–pyridinium and imidazole–acid heterosynthons in the binary and ternary adducts. The intermolecular interactions between ACF and the coformer are analyzed by Hirshfeld surfaces, 2D fingerprint plots, and an energy framework. The permeability of ACF increases in binary and ternary systems with selected coformers. The fast dissolution and high permeability of ACF-PIP make this salt an improved crystalline formulation of acefylline.

1 aAllu, Suryanarayana1 aGarai, Abhijit1 aChernyshev, Vladimir, V.1 aNangia, Ashwini, K. uhttps://library.ncl.res.in/content/synthesis-ternary-cocrystals-salts-and-hydrates-acefylline-enhanced-dissolution-and-high