02498nas a2200265   4500008004100000245016500041210006900206260000800275300001500283490000600298520155600304100002101860700001801881700002001899700001701919700002301936700002101959700001801980700002401998700002202022700001402044700002302058700002202081856012902103       2017                        eng d00aSelective isolation and eradication of E. coli associated with urinary tract infections using anti-fimbrial modified magnetic reduced graphene oxide nanoheaters0 aSelective isolation and eradication of E coli associated with ur  cOCT  a 8133-81420 v53 aThe fast and efficient elimination of pathogenic bacteria from water, food or biological samples such as blood remains a challenging task. Magnetic isolation of bacteria from complex media holds particular promise for water disinfection and other biotechnological applications employing bacteria. When it comes to infectious diseases such as urinary tract infections, the selective removal of the pathogenic species in complex media such as human serum is also of importance. This issue can only be accomplished by adding pathogen specific targeting sites onto the magnetic nanostructures. In this work, we investigate the potential of 2-nitrodopamine modified magnetic particles anchored on reduced graphene oxide (rGO) nanocomposites for rapid capture and efficient elimination of E. coli associated with urinary tract infections (UTIs) from water and serum samples. An optimized magnetic nanocarrier achieves a 99.9% capture efficiency even at E. coli concentrations of 1 x 10(1) cfu mL(-1) in 30 min. In addition, functionalization of the nanostructures with poly(ethylene glycol) modified pyrene units and anti-fimbrial E. coli antibodies allowed specific elimination of E. coli UTI89 from serum samples. Irradiation of the E. coli loaded nanocomposite with a near-infrared laser results in the total ablation of the captured pathogens. This method can be flexibly modified for any other pathogenic bacteria, depending on the antibodies used, and might be an interesting alternative material for a magnetic-based body fluid purification approach.1 aHalouane, Fatima1 aJijie, Roxana1 aMeziane, Dalila1 aLi, Chengnan1 aSingh, Santosh, K.1 aBouckaert, Julie1 aJurazek, Jean1 aKurungot, Sreekumar1 aBarras, Alexandre1 aLi, Musen1 aBoukherroub, Rabah1 aSzunerits, Sabine  uhttps://library.ncl.res.in/content/selective-isolation-and-eradication-e-coli-associated-urinary-tract-infections-using-anti01983nas a2200229   4500008004100000245014000041210006900181260000800250300001200258490000800270520115600278100002201434700002101456700001801477700002301495700002401518700002001542700002001562700002301582700002201605856012601627       2018                        eng d00aSensitive electrochemical detection of cardiac troponin I in serum and saliva by nitrogen-doped porous reduced graphene oxide electrode0 aSensitive electrochemical detection of cardiac troponin I in ser  cJUN  a180-1870 v2623 aCardiovascular diseases pose one of the highest mortality risks among all diseases in developed countries, steadily increasing the burden on the health systems. Early diagnosis of cardiovascular diseases has consequently become highly important to decrease mortality and to use more adapted therapeutic decisions. We demonstrate here the utility of nitrogen-doped reduced graphene oxide (N-prGO) for detecting and quantifying of cardiac troponin I (cTnI), a key human cardiac protein biomarker, under physiologically relevant conditions. Non-covalent modification of N-prGO by 1-pyrenecarboxylic acid (py-COOH) and poly(ethylene glycol) modified pyrene (py-PEG) ligands allowed the covalent integration of Tro4 aptamer, known for its high selectivity towards cTnI. Using differential pulse voltammetry (DPV), a label-free electrochemical sensor for cTnI for concentrations down to 1 pgmL(-1) in human serum could be obtained. This sensitive detection arises from the integration of a porous nanomaterial with excellent electrochemical properties being easily amendable to site-specific surface modification. (C) 2018 Elsevier B.V. All rights reserved.1 aChekin, Fereshteh1 aVasilescu, Alina1 aJijie, Roxana1 aSingh, Santosh, K.1 aKurungot, Sreekumar1 aIancu, Madalina1 aBadea, Gabriela1 aBoukherroub, Rabah1 aSzunerits, Sabine  uhttps://library.ncl.res.in/content/sensitive-electrochemical-detection-cardiac-troponin-i-serum-and-saliva-nitrogen-doped