01669nas a2200217   4500008004100000245012500041210006900166260000800235300001400243490000700257520088500264100002101149700002301170700002201193700002101215700002501236700001901261700002101280700002001301856013001321       2017                        eng d00aIdentification and synthesis of mycalol analogues with improved potency against anaplastic thyroid carcinonia cell lines0 aIdentification and synthesis of mycalol analogues with improved   cAPR  a1125-11330 v803 aThe marine metabolite mycalol (1) has a specific inhibitory activity on cells of anaplastic thyroid carcinoma (ATC), a very aggressive and rare cancer that does not have effective conventional therapy. In this study, we describe six new related analogues (2-7) that differ in the length of the terminal alkyl residue and the presence of acetate or 3S-hydroxybutyrate (3S)-3HB as a substituent at C-19. Despite the structural' analogies, some of the new members were significantly more-cytotokic than 1 on cell lines,derivecl from human ATC. Structures inclusive of the 2'R,3R,4S,7R,8S,19R absolute configuration were asigned to 2-7 on the basis of detailed spectroscopic analysis, synthesis of different isomers, and application of ECD and Mosher's methods. This work led to the identification of mycal61-578 (3) as the most potent analogue, with an IC50 of 2.3 mu M on FRO cells:1 aCutignano, Adele1 aSeetharamsingh, B.1 aD'Angelo, Daniela1 aNuzzo, Genoveffa1 aKhairnar, Pankaj, V.1 aFusco, Alfredo1 aReddy, Srinivasa1 aFontana, Angelo  uhttps://library.ncl.res.in/content/identification-and-synthesis-mycalol-analogues-improved-potency-against-anaplastic-thyroid