02475nas a2200265   4500008004100000022001400041245013200055210006900187260000900256300001100265490000800276520158300284653002401867653000801891653001301899653001801912653001001930653002301940100002501963700002701988700002602015700001902041700002302060856012602083       2020                        eng d  a0378-517300aStimuli-responsive biodegradable polyurethane nano-constructs as a potential triggered drug delivery vehicle for cancer therapy0 aStimuliresponsive biodegradable polyurethane nanoconstructs as a  cOCT   a1197810 v5883 a<p>Polyurethanes (PUs) constitute an essential class of stimuli-responsive and biodegradable material, which has significantly contributed to the advancement of polymers utilization in the biomedical field. The bio-erodible PUs construct an active corridor for facilitating drug into tumor cells, which has significantly impacted the progression of nano-micellar delivery systems. The self-assembled colloidal PUs pose distinctive features such as enhancing the solubility of hydrophobic chemotherapeutics, rapid cellular uptake, triggered erosion and drug release, bio-stimulus sensitivity, improvement in the targeting and proficiency of bioactive. Cationic PUs can easily be condensed with genetic material to form polyplexes and have shown excellent transfection efficiency for potential gene therapy against various cancers. Their modifiable chemistry offers a tool to impart the desired multifunctionality such as biocompatibility, sensitivity to pH, redox, temperature, enzyme, etc. and ligand conjugation for active targeting. These diverse exceptional properties make them excellent nano-carrier for a variety of bioactive, including chemotherapeutic drugs, DNA, RNA, and diagnostic moieties to the target tissue or cells. The PUs based nano-devices have certainly uncovered the path to achieve ideal systems for controlled personalized therapy. The literature discussed in this review shed light on the research innovations carried out in the last ten years for the development of multifunctional PUs for triggered delivery of bioactive to treat various cancers.</p>
10aCancer nanomedicine10aGSH10amicelles10aPolyurathanes10aredox10aStimuli-responsive1 aGajbhiye, Kavita, R.1 aChaudhari, Bhushan, P.1 aPokharkar, Varsha, B.1 aPawar, Atmaram1 aGajbhiye, Virendra  uhttps://library.ncl.res.in/content/stimuli-responsive-biodegradable-polyurethane-nano-constructs-potential-triggered-drug