01851nas a2200217   4500008004100000022001400041245010800055210006900163260000800232300001500240490000600255520105700261653003101318653003501349653002501384653001801409653002201427100002801449700002701477856012901504       2023                        eng d  a2365-654900aRobust optimization and characterization of MCM-41 nanoparticle synthesis using modified sol-gel method0 aRobust optimization and characterization of MCM41 nanoparticle s  cMAR  ae2022049680 v83 a<p>
	Mesoporous silica nanoparticles (MSN) for drug delivery application requires great expertise to synthesize small sized monodisperse particles. We aimed at synthesizing and optimizing MCM-41 particles with the modified Stober's method by adjusting factors such as concentrations of cetyltrimethylammonium bromide (CTAB), sodium hydroxide (NaOH) and water (H2O) with respect to tetraethyl orthosilicate (TEOS), and a process parameter (stirring). We comprehended that the reactants determined the shape and size of both the particles and pores. Upon extensive characterization we report the synthesis of spherical particles of similar to 70 nm size in a monodisperse population; the structures had hexagonal ordered pores of diameter 3.071 nm and volume 3.124 cm(3)/g; the total surface area of 3410.648 m(2)/g of the particles was covered with silanol groups that aid in functionalization; the particles exhibited great thermal stability. Thus, the extensive optimization fabricated robust MCM-41 particles fit for drug delivery application.</p>
10acharacterization technique10adynamic light scattering (DLS)10amesoporous materials10aNanoparticles10asol gel processes1 aShende, Rajnigandha, A.1 aChaudhari, Bhushan, P.  uhttps://library.ncl.res.in/content/robust-optimization-and-characterization-mcm-41-nanoparticle-synthesis-using-modified-sol