01229nas a2200193   4500008004100000245010900041210006900150260000800219300001200227490000700239520052000246100002200766700002300788700002100811700002500832700002600857700002700883856012500910       2017                        eng d00aNew and efficient enantioselective synthesis of both enantiomers of the calcium channel blocker bepridil0 aNew and efficient enantioselective synthesis of both enantiomers  cJAN  a824-8290 v413 aA concise and efficient enantioselective synthesis of both enantiomers of bepridil, a calcium channel blocker, is reported. Jacobsen's hydrolytic kinetic resolution method was utilized to resolve racemic 2-(isobutoxymethyl) oxirane. The incorporation of the succinimide moiety by the Mitsunobu reaction, which was investigated in detail, occurred without any loss of enantioselectivity. Using this strategy, both enantiomers of the target molecule were obtained in good yield and with high enantiopurity (ee > 99%).1 aMujahid, Mohammad1 aSubramanian, Jambu1 aNalla, Viswanadh1 aSasikumar, Murugesan1 aKunte, Sunita, Sharad1 aMuthukrishnan, Murugan  uhttps://library.ncl.res.in/content/new-and-efficient-enantioselective-synthesis-both-enantiomers-calcium-channel-blocker