01275nas a2200229 4500008004100000022001400041245013600055210006900191260000900260300001100269490000700280520048300287653000600770653001600776653003100792653002100823653001900844653002000863100002800883700000500911856012900916 2020 eng d a0040-403900aAttempted synthesis of central furopyran core of diocollettines A via a gold-catalyzed cascade 1,6-diyne cycloisomerization process0 aAttempted synthesis of central furopyran core of diocollettines  cOCT  a1523670 v613 a

Herein, we describe an Au-catalyzed cascade diyne cycloisomerization process that was projected to construct the central furopyran bicyclic core of Diocollettines A. Our intended strategy for the annulation of the third thf ring is based on epoxidation and subsequent intramolecular acetalization. However, the initial alkynol cyclization occurred in an undesired 5-exo-dig mode, ultimately leading to an undesired furopyran. (C) 2020 Elsevier Ltd. All rights reserved.

10a110a6-Hexadiyne10aAlkynol cycloisomerization10aDiocollettines A10aGold-catalysis10aTotal synthesis1 aMullapudi, Venkannababu1 a uhttps://library.ncl.res.in/content/attempted-synthesis-central-furopyran-core-diocollettines-gold-catalyzed-cascade-16-diyne