01595nas a2200193   4500008004100000245013500041210006900176260000800245300001400253490000700267520084500274100001901119700002201138700002001160700003101180700003701211700002401248856012901272       2013                        eng d00aSelf-assembly to function: design, synthesis and broad spectrum antimicrobial properties of short hybrid E-vinylogous lipopeptides0 aSelfassembly to function design synthesis and broad spectrum ant  cNOV  a8468-84740 v563 aNonribosomal E-vinylogous gamma-amino acids are widely present in many peptide natural products and have been exploited as inhibitors for serine and cysteine proteases. Here, we are reporting the broad spectrum antimicrobial properties and self-assembled nanostructures of various hybrid lipopeptides composed of 1:1 alternating alpha-and E-vinylogous residues. Analysis of the results revealed that self-assembled nanostructures also play a significant role in the antimicrobial and hemolytic activities. In contrast to the alpha-peptide counterparts, vinylogous hybrid peptides displayed excellent antimicrobial properties against various bacterial and fungal strains. Peptides that adopted nanofiber structures displayed less hemolytic activity, while peptides that adopted nanoneedle structures displayed the highest hemolytic activity.1 aShankar, Shiva1 aBenke, Sushil, N.1 aNagendra, Narem1 aSrivastava, Prabhakar, Lal1 aThulasiram, Hirekodathakallu, V.1 aGopi, Hosahudya, N.  uhttps://library.ncl.res.in/content/self-assembly-function-design-synthesis-and-broad-spectrum-antimicrobial-properties-short