01845nas a2200157   4500008004100000022001400041245010300055210006900158260000800227300001000235520123900245100003401484700002701518700001701545856012501562       2019                        eng d  a0021-899500aRole of particle morphology in the yielding behavior of dense thermosensitive microgel suspensions0 aRole of particle morphology in the yielding behavior of dense th  cOCT  a486253 a<p>The yielding behavior of dense thermosensitive microgel suspensions of poly(N-isopropylacrylamide) with two different particle morphologies viz core-shell (CS) morphology and particles with uniform crosslink density were studied. Structural properties were examined using dynamic light scattering and yielding behavior was investigated by nonlinear oscillatory rheology. Suspensions of particles with uniform crosslinking density showed a typical hard sphere like behavior with the loss modulus (G `') exhibiting a single peak due to cage breaking while CS type particles shows a double yielding at different ranges of strain similar to that seen in attractive colloidal glasses. The first yielding process in CS microgels is interpreted as due to the disentanglement of the overlapped polymer chains from the shells of the neighboring microgels and the second yielding process due to the breakage of cages formed by neighboring microgel particles. Current study suggests that the interpenetration of polymer chains at high concentrations sets in an attractive like potential leading to double yielding phenomena in an otherwise purely repulsive system. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48625.</p>
1 aJathavedan, Kiran, Kaithakkal1 aKanheerampockil, Fayis1 aBhat, Suresh  uhttps://library.ncl.res.in/content/role-particle-morphology-yielding-behavior-dense-thermosensitive-microgel-suspensions01933nas a2200193   4500008004100000020001400041245008400055210006900139260000800208300001600216490000700232520135200239100002501591700001701616700001701633700002301650700001901673856004701692       2021                        eng d  a2191-164900aResveratrol loaded cubic phase nanoparticles with enhanced oral bioavailability0 aResveratrol loaded cubic phase nanoparticles with enhanced oral   cDEC  a1108 - 11180 v113 aResveratrol (RES), a naturally occurring hydrophobic polyphenolic compound, has shown potential anticancer activity. However, due to low aqueous solubility and extensive first pass metabolism (primarily by cytochrome enzymes), it shows poor oral bioavailability. In the present work, novel RES loaded cubosomes of glycerol monooleate (GMO) and Gelucire 44/14 (GL44) (RES-Cubs) were prepared. RES-Cubs were prepared by emulsion evaporation technique and optimized using 32 factorial design. The optimized RES-Cubs were assessed for particle size, zeta potential, entrapment efficiency, FTIR, TEM, SAXS, in vitro resveratrol release and oral bioavailability. RES-Cubs showed an average particle size of 121.7 ± 2.54 nm with adequate entrapment efficiency of about 82.0 ± 2.35% w/w. The analysis of SAXS profile of RES-Cubs revealed Pn3m crystallographic space group containing diamond cubic phase. In vitro RES release profile of RES-Cubs exhibited markedly sustained release of resveratrol. Furthermore, RES-Cubs demonstrated considerable enhancement in oral bioavailability (ninefold) of resveratrol as compared to RES alone. The developed RES loaded cubosomes bearing cytochrome enzyme inhibitor property can act as promising nanocarrier in the delivery of lipophilic drugs with a drawback of in vivo degradation by cytochrome enzymes.1 aRawat, Neeraj, Kumar1 aTorris, Arun1 aBhat, Suresh1 aMahadik, Kakasaheb1 aPatil, Sharvil  uhttps://doi.org/10.1007/s12668-021-00892-902123nas a2200193   4500008004100000245010300041210006900144260000800213300001600221490000700237520143400244100001801678700002001696700001401716700001701730700002301747700002701770856013201797       2021                        eng d00aRigidity dictates spontaneous helix formation of thermoresponsive colloidal chains in poor solvent0 aRigidity dictates spontaneous helix formation of thermoresponsiv  cDEC  a19702-197110 v153 aThe formation of helical motifs typically requires specific directional interactions. Here, we demonstrate that isotropic interparticle attraction can drive self-assembly of colloidal chains into thermo-reversible helices, for chains with a critical level of backbone rigidity. We prepare thermoresponsive colloidal chains by cross-linking PNIPAM microgel-coated polystyrene colloids (“monomers”), aligned in an AC electric field. We control the chain rigidity by varying cross-linking time. Above the LCST of PNIPAM, there is an effective attraction between monomers so that the colloidal chains are in a bad solvent. On heating, the chains decrease in size. For the most rigid chains, the decrease is modest and is not accompanied by a change in shape. Much less rigid chains form relatively compact structures, resulting in a large increase in the local monomer density. Unusually, chains with intermediate rigidity spontaneously assemble into helical structures. The chain helicity increases with temperature and plateaus above the collapse transition temperature of the microgel particles. We simulate a minimal model that captures the spontaneous emergence of the helical conformations of the polymeric chain and provides insight into this shape transition. Our work suggests that a purely mechanical instability for semiflexible filaments can drive helix formation, without the need to invoke directional interactions.1 aBiswas, Bipul1 aMitra, Debarshi1 aKP, Fayis1 aBhat, Suresh1 aChatterji, Apratim1 aKumaraswamy, Guruswamy  uhttps://library.ncl.res.in/content/rigidity-dictates-spontaneous-helix-formation-thermoresponsive-colloidal-chains-poor-solvent