01659nas a2200205   4500008004100000245012600041210006900167260000800236300001200244490000700256520090900263100001901172700002201191700002301213700002201236700002201258700002401280700001901304856013001323       2017                        eng d00aSynthesis and biological evaluation of 1,2,4-triazole-3-thione and 1,3,4-oxadiazole-2-thione as anti-mycobacterial agents0 aSynthesis and biological evaluation of 124triazole3thione and 13  cJAN  a200-2090 v903 aResistance among dormant mycobacteria leading to multi-drug resistant (MDR) and extremely-drug resistant(XDR) tuberculosis is one of the major threats. Hence, a series of 1,2,4-triazole-3-thione and 1,3,4-oxadiazole-2-thione derivatives (4a-5c) have been synthesised and screened for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra (H37Ra). Thetriazolethiones4b and 4v showed high anti-tubercular activity (both MIC and IC50) against the dormant H37Ra by in vitro and ex vivo. They were shown to have more specificity towards mycobacteria than other gram-negative and gram- positive pathogenic bacteria. The cytotoxicity was almost insignificant up to 100 μg/mL against THP-1, A549 and PANC-1 human cancer cell lines, and solubility was high in aqueous solution, indicating the potential of developing these compounds further as novel therapeutics against tuberculosis infection.1 aSonawane, Amol1 aRode, Navnath, D.1 aNawale, Laxman, U.1 aJoshi, Rohini, R.1 aJoshi, Ramesh, A.1 aLikhite, Anjali, P.1 aSarkar, Dhiman  uhttps://library.ncl.res.in/content/synthesis-and-biological-evaluation-124-triazole-3-thione-and-134-oxadiazole-2-thione-anti