02420nas a2200277   4500008004100000022001400041245008900055210006900144260007500213300001400288490000700302520146100309653001301770653001701783653001401800653001501814653002301829653002801852653002501880100002301905700002301928700002101951700002701972700002401999856011902023       2012                        eng d  a0724-874100aMicrostructural elucidation of self-emulsifying system: effect of chemical structure0 aMicrostructural elucidation of selfemulsifying system effect of   a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGER/PLENUM PUBLISHERScAUG  a2180-21880 v293 a<p>Self-emulsifying systems (SES) emulsify spontaneously to produce fine oil-in-water emulsion when introduced into aqueous phase. The self-emulsification process plays an important role during formation of emulsion. The objective of current work was to understand and explore the inner structuration of SES through controlled hydration and further to study the influence of additive on the same which ultimately governs performance of final formulation in terms of droplet size. Droplet size of final formulations containing structural analogues of ibuprofen was determined. Microstructural properties of intermediate hydrated regimes of SES were investigated using techniques such as small angle X-ray scattering, differential scanning calorimetry and rheology. The current work established inverse relationship between droplet size of the formulations containing structural analogues of ibuprofen and their Log P values. Microstructural analysis of intermediate hydrated regimes of the prepared samples showed formation of local lamellar structure. Structural analogues of ibuprofen significantly altered microstructure of lamellae which was well correlated with the droplet size of final formulations. In vitro drug release study showed increase in dissolution rate of lipophillic drugs when formulated as SES. The current work emphasizes the fact that tailor-made formulations can be prepared by controlling the properties of intermediate regimes.</p>10aemulsion10aflurbiprofen10aibuprofen10aketoprofen10alamellar structure10aself-emulsifying system10astructural analogues1 aPatil, Sharvil, S.1 aVenugopal, Edakkal1 aBhat, Suresh, K.1 aMahadik, Kakasaheb, R.1 aParadkar, Anant, R.  uhttps://library.ncl.res.in/content/microstructural-elucidation-self-emulsifying-system-effect-chemical-structure-002603nas a2200265   4500008004100000022001400041245010800055210006900163260007100232300001200303490000600315520165100321653001301972653002301985653001902008653001902027653001302046653002802059100002302087700002302110700002102133700002702154700002402181856013202205       2012                        eng d  a1543-838400aProbing influence of mesophasic transformation on performance of self-emulsifying system: effect of ion0 aProbing influence of mesophasic transformation on performance of  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcFEB  a318-3240 v93 a<p>Self-emulsifying systems are mixtures of oils and surfactants, ideally isotropic, sometimes including cosolvents, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastrointestinal tract. The process of self-emulsification has remained the center of attraction for most researchers. Controlled hydration of self-emulsifying systems shows formation of an intermediate gel phase which upon rupture forms an emulsion. Current work was undertaken to understand and explore the microstructural properties of intermediate gel phase which are believed to influence the performance (droplet size) of the final formulation. The effect of additives on microstructural properties of intermediate gel phase has also been investigated. Microstructural elucidation of hydrated samples of intermediate regimes was done by using techniques such as small angle X-ray scattering, differential scanning calorimetry and rheology. Samples from intermediate regimes showed formation of local lamellar structure which swelled with hydration. In the present work, the effect of addition of salt form of naproxen (sodium and potassium) and naproxen (base) on microstructural properties of intermediate regimes was investigated. Systems containing naproxen salts formed larger droplets whereas naproxen base formed smaller ones. Microstructural properties of intermediate lamellar structures were well correlated with performance of the final formulation. The current studies indicate that by controlling the properties of intermediate regimes optimized formulations with desired performance can be tailor-made.</p>10aemulsion10alamellar structure10aliquid crystal10aMicrostructure10aNaproxen10aself-emulsifying system1 aPatil, Sharvil, S.1 aVenugopal, Edakkal1 aBhat, Suresh, K.1 aMahadik, Kakasaheb, R.1 aParadkar, Anant, R.  uhttps://library.ncl.res.in/content/probing-influence-mesophasic-transformation-performance-self-emulsifying-system-effect-ion-0