01806nas a2200301   4500008004100000022001400041245008900055210006900144260007300213300001400286490000800300520081000308653002701118653001601145653001301161653001701174653002501191653001001216653001001226100001801236700002201254700002701276700001601303700001701319700002601336700002601362856011601388       2008                        eng d  a0014-579300aTaxol and 10-deacetylbaccatinIII induce distinct changes in the dynamics of caveolae0 aTaxol and 10deacetylbaccatinIII induce distinct changes in the d  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcOCT  a3595-36000 v5823 a<p>Taxol treatment of HeLa cells resulted in a transient recruitment of Caveolin-1 to the cell surface followed by internalization. Interestingly, 20 min after 10-deacetylbaccatinIII (10-DAB) treatment, the caveolae displayed faster `kiss and run' dynamics while BaccatinIII (BacIII) did not induce any change. Sustained phosphorylation of Caveolin-1 is observed upon treatment and between Taxol and 10-DAB, the former shows phosphorylated Raf-1, ERK1/2 and hyperphosphorylated Bcl-2 while the later showed much less magnitude of the same. BacIII treatment did not induce phosphorylation of Raf-1 or Bcl-2. It is possible that Taxol might act on multiple targets and the side chain may be crucial. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.</p>10a10-DeacetylbaccatinIII10aBaccatinIII10aCaveolae10aCytotoxicity10aKiss and run dynamic10aTaxol10aTIRFM1 aAhmed, Neesar1 aDasari, Sreekanth1 aSrivastava, Saumya, S.1 aSneh, Amita1 aAhmad, Absar1 aKhan, Mohammad, Islam1 aKrishnasastry, M., V.  uhttps://library.ncl.res.in/content/taxol-and-10-deacetylbaccatiniii-induce-distinct-changes-dynamics-caveolae-0