01167nas a2200217   4500008004100000022001400041245011000055210006900165260010600234300001400340490000700354520030200361653001800663653002000681653001700701653002100718100002600739700002200765700003000787856013200817       2015                        eng d  a0040-403900aEnantioselective synthesis of (+)-hygroline and (+)-pseudohygroline via Keck allylation and CBS reduction0 aEnantioselective synthesis of hygroline and pseudohygroline via   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a4704-47050 v563 a<p>An enantioselective synthesis of (+)-hygroline and (+)-pseudohygroline has been achieved in high optical purity (98% ee) from readily available 1,4-butanediol. The synthesis strategy employs a Keck allylation, CBS reduction, and Wacker oxidation. (C) 2015 Elsevier Ltd. All rights reserved.</p>10aCBS reduction10aKeck allylation10aPyrrolidines10aWacker oxidation1 aBhoite, Shubhangi, P.1 aKamble, Rohit, B.1 aSuryavanshi, Gurunath, M.  uhttps://library.ncl.res.in/content/enantioselective-synthesis-hygroline-and-pseudohygroline-keck-allylation-and-cbs-reduction-001828nas a2200145   4500008004100000245011600041210006900157260000800226520122000234100002601454700002201480700002401502700002601526856013001552       2019                        eng d00aAgNO3-Catalysed intramolecular cyclization: access to functionalized cyclopentanones and spiro-cyclopentanones 0 aAgNO3Catalysed intramolecular cyclization access to functionaliz  cAUG3 a<p><span class="hitHilite">An</span> efficient <span class="hitHilite">AgNO3-catalysed</span> method has been developed <span class="hitHilite">for</span> <span class="hitHilite">the</span> <span class="hitHilite">synthesis</span> <span class="hitHilite">of</span> <span class="hitHilite">functionalized</span> <span class="hitHilite">cyclopentanones</span> and <span class="hitHilite">spiro</span>-<span class="hitHilite">cyclopentanones</span> through <span class="hitHilite">intramolecular</span> <span class="hitHilite">cyclization</span> between ynones and cyanoacrylate/aryl/alkylidene malononitrile using DBU as <span class="hitHilite">a</span> base. Easy availability <span class="hitHilite">of</span> starting materials and <span class="hitHilite">mild</span> reaction conditions makes this protocol more feasible over previously reported methods. <span class="hitHilite">The</span> <span class="hitHilite">functionalized</span> <span class="hitHilite">cyclopentanones</span> and <span class="hitHilite">spiro</span>-<span class="hitHilite">cyclopentanones</span> were synthesized in good <span class="hitHilite">to</span> excellent yields with <span class="hitHilite">a</span> broad substrate scope.</p>
1 aBhoite, Shubhangi, P.1 aBansode, Ajay, H.1 aBurate, Pralhad, A.1 aSuryayanshi, Gurunath  uhttps://library.ncl.res.in/content/agno3-catalysed-intramolecular-cyclization-access-functionalized-cyclopentanones-and-spiro01276nas a2200169   4500008004100000022001400041245017700055210006900232260000900301300001600310490000700326520059500333100002600928700002300954700002600977856010301003       2020                        eng d  a0022-326300aRadical rearrangement of aryl/alkylidene malononitriles via aza michael addition/decynoformylation/addition sequence: an access to alpha-aminonitriles and alpha-aminoamides0 aRadical rearrangement of arylalkylidene malononitriles via aza m  cDEC   a14858-148650 v853 a<p>An efficient, safe, and environmentally friendly tertiary butyl hydrogen peroxide (TBHP)-mediated rearrangement of aryl/alkylidene malononitrile with anilines has been developed with in situ generation of HCN as the cyanide source for the synthesis of substituted alpha-aminonitriles and alpha-aminoamide. A diverse set of alpha-aminonitriles and alpha-aminoamides was efficiently synthesized in good to excellent yields. This method features a broad substrate scope and good functional group tolerance, and the in situ-generated HCN bypasses the use of an external cyanide source.</p>
1 aBhoite, Shubhangi, P.1 aBansodes, Ajay, H.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/radical-rearrangement-arylalkylidene-malononitriles-aza-michael02778nas a2200325   4500008004100000245012400041210006900165260000800234300000700242490000700249520169500256653002401951653002001975653002701995653002302022653001702045653001402062653002002076653002802096100002202124700002202146700002202168700002302190700002602213700001902239700002202258700001802280700002202298856013202320       2023                        eng d00aAntiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection0 aAntiviral and ROS scavenging potential of Carica papaya Linn and  cMAR  a820 v233 a<p>
	Antiretroviral therapy is the only treatment option for HIV-infected patients; however, it has certain drawbacks in terms of developing multiple toxic side effects. Thus, there is a continuous need to explore safe and efficacious anti-retroviral agents. Carica papaya Linn and Psidium guajava are known for their various biological activities. In this study, we characterized the bioactive fractions of methanolic leaves extract from both plants using the High-resolution electrospray ionization mass spectrometry (HR-ESI-MS) technique, followed by the investigation of their potential as anti-HIV-1 and antioxidant agents through in vitro mechanistic assays. The anti-HIV-1 activity was examined in TZM-bl cells through luciferase gene assay against two different clades of HIV-1 strains, whereas the intracellular ROS generation was analyzed by Fluorescence-Activated Cell Sorting. Additionally, the mechanisms of action of these phyto-extracts were determined through the Time-of-addition assay. The characterization of Carica papaya Linn and Psidium guajava leaves extract through HR-ESI-MS fragmentation showed high enrichment of various alkaloids, glycosides, lipids, phenolic compounds, terpenes, and fatty acids like bioactive constituents. Both the phyto-extracts were found to be less toxic and exhibited potent antiviral activity against HIV-1 strains. Furthermore, the phyto-extracts also showed a decreased intracellular ROS in HIV-1 infected cells due to their high antioxidant potential. Overall, our study suggests the anti-HIV-1 potential of Carica papaya Linn and Psidium guajava leaves extract due to the synergistic action of multiple bioactive constituents.</p>
10aanti-HIV-1 activity10aAnti-retroviral10aBioactive constituents10aCarica papaya Linn10aCytotoxicity10aHR-ESI-MS10aPsidium guajava10areactive oxygen species1 aJadaun, Pratiksha1 aShah, Prachibahen1 aHarshithkumar, R.1 aSaid, Madhukar, S.1 aBhoite, Shubhangi, P.1 aBokuri, Sowmya1 aRavindran, Selvan1 aMishra, Neetu1 aMukherjee, Anupam  uhttps://library.ncl.res.in/content/antiviral-and-ros-scavenging-potential-carica-papaya-linn-and-psidium-guajava-leaves-extract01201nas a2200205   4500008004100000022001400041245014000055210006900195260000800264300001400272490000700286520043800293653001800731653002800749653001500777653002100792100002600813700002600839856013000865       2023                        eng d  a1478-641900aEnantioselective synthesis of (+)-Sedridine, (-)-Allosedridine and their N-Methyl analogs via Maruoka-Keck allylation and CBS reduction0 aEnantioselective synthesis of Sedridine Allosedridine and their   cOCT  a3388-33940 v373 a<p>
	A simple synthetic approach has been developed for the enantioselective total synthesis of (+)-Sedridine, (-)-Allosedridine and their analogs such as (+)-N- Methyl Sedridine and (-)-N-Methylallosedridine. The synthesis was achieved by using commercially available starting materials via Maruoka-Keck allylation, Wacker oxidation, and CBS reduction. The synthetic root provides a good diastereomeric ratio and high yields.</p>
10aCBS reduction10aMaruoka-Keck allylation10aPiperidine10aWacker oxidation1 aBhoite, Shubhangi, P.1 aSuryavanshi, Gurunath  uhttps://library.ncl.res.in/content/enantioselective-synthesis-sedridine-allosedridine-and-their-n-methyl-analogs-maruoka-keck00896nas a2200241   4500008004100000245013800041210006900179260000800248490000700256653001400263653001800277100002200295700002200317700002400339700002600363700002600389700002600415700001900441700002600460700001800486700002200504856012800526       2024                        eng d00aMitochondrial resilience and antioxidant defence against HIV-1: unveiling the power of Asparagus racemosus extracts and Shatavarin IV0 aMitochondrial resilience and antioxidant defence against HIV1 un  cOCT0 v1510aIN-SILICO10aINHIBIT HIV-11 aJadaun, Pratiksha1 aHarshithkumar, R.1 aSeniya, Chandrabhan1 aGaikwad, Shraddha, Y.1 aBhoite, Shubhangi, P.1 aChandane-Tak, Madhuri1 aBorse, Swapnil1 aChavan-Gautam, Preeti1 aTillu, Girish1 aMukherjee, Anupam  uhttps://library.ncl.res.in/content/mitochondrial-resilience-and-antioxidant-defence-against-hiv-1-unveiling-power-asparagus