01684nas a2200277   4500008004100000022001400041245016300055210006900218260010600287300001400393490000700407520057500414653002400989653003101013653002801044653003101072653002101103100002101124700002001145700001901165700001801184700002301202700002601225700002601251856012901277       2007                        eng d  a0968-089600aSynthesis and evaluation of antifungal properties of a series of the novel 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and its analogues0 aSynthesis and evaluation of antifungal properties of a series of  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a6705-67150 v153 a<p>A series of 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and various analogues have been synthesized in excellent isolated yields starting from various arylidenemalononitrile and 3-amino-2-cyclohexen-1-one in 1-propanol as solvent at reflux temperature in the absence of any added catalyst. All the synthesized compounds were evaluated for their antifungal activity. The relationship between functional group variation and biological activity of the evaluated compounds is discussed in the article. (C) 2007 Elsevier Ltd. All rights reserved.</p>10aAntifungal activity10aantiproliferative activity10aarylidenemalononitriles10aarylquinoline carbonitrile10aMichael addition1 aGholap, Atul, R.1 aToti, Kiran, S.1 aShirazi, Fazal1 aKumari, Ratna1 aBhat, Manoj, Kumar1 aDeshpande, Mukund, V.1 aSrinivasan, Kumar, V.  uhttps://library.ncl.res.in/content/synthesis-and-evaluation-antifungal-properties-series-novel-2-amino-5-oxo-4-phenyl-5678-001714nas a2200265   4500008004100000022001400041245016400055210006900219260010600288300001600394490000700410520067400417653002601091653002401117653001701141653001401158653001601172653002001188100002101208700002001229700001901249700002601268700002601294856012801320       2008                        eng d  a0040-402000aEfficient synthesis of antifungal pyrimidines via palladium catalyzed Suzuki/Sonogashira cross-coupling reaction from Biginelli 3,4-dihydropyrimidin-2(1H)-ones0 aEfficient synthesis of antifungal pyrimidines via palladium cata  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a10214-102230 v643 a<p>An efficient regioselective approach to the synthesis of tetrasubstituted pyrimidines was developed by sequential functionalization of easily available Biginelli 3,4-dihydropyrimidine-2(1H)-ones via dehydrogenation, chlorination followed by palladium catalyzed C-C Suzuki/Sonogashira coupling reaction. All the synthesized compounds were evaluated in vitro for their antifungal activities against Candida albicans, Cryptococcus neoformans, Benjaminiella poitrasii, Yarrowia lipolytica, and Fusarium oxysporum, and antibacterial activities against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. (c) 2008 Elsevier Ltd. All rights reserved.</p>10aAntifungal activities10aBiginelli compounds10achlorination10aOxidation10aPyrimidines10aSuzuki coupling1 aGholap, Atul, R.1 aToti, Kiran, S.1 aShirazi, Fazal1 aDeshpande, Mukund, V.1 aSrinivasan, Kumar, V.  uhttps://library.ncl.res.in/content/efficient-synthesis-antifungal-pyrimidines-palladium-catalyzed-suzukisonogashira-cross-0