01959nas a2200193   4500008004100000022001400041245014100055210006900196260008800265300001200353490000700365520116900372100001701541700001801558700001501576700003101591700001801622856012501640       2015                        eng d  a2159-333700aCyclic cationic peptides containing sugar amino acids selectively distinguishes and inhibits maturation of pre-mirnas of the same family0 aCyclic cationic peptides containing sugar amino acids selectivel  a140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USAbMARY ANN LIEBERT, INCcDEC  a323-3290 v253 a<p>The discovery of microRNAs (miRNAs) has added a new dimension to the gene regulatory networks, making aberrantly expressed miRNAs as therapeutically important targets. Small molecules that can selectively target and modulate miRNA levels can thus serve as lead structures. Cationic cyclic peptides containing sugar amino acids represent a new class of small molecules that can target miRNA selectively. Upon treatment of these small molecules in breast cancer cell line, we profiled 96 therapeutically important miRNAs associated with cancer and observed that these peptides can selectively target paralogous miRNAs of the same seed family. This selective inhibition is of prime significance in cases when miRNAs of the same family have tissue-specific expression and perform different functions. During these conditions, targeting an entire miRNA family could lead to undesired adverse effects. The selective targeting is attributable to the difference in the three-dimensional structures of precursor miRNAs. Hence, the core structure of these peptides can be used as a scaffold for designing more potent inhibitors of miRNA maturation and hence function.</p>1 aNahar, Smita1 aBose, Debojit1 aPal, Sudip1 aChakraborty, Tushar, Kanti1 aMaiti, Souvik  uhttps://library.ncl.res.in/content/cyclic-cationic-peptides-containing-sugar-amino-acids-selectively-distinguishes-and-0