01863nas a2200145   4500008004100000245011200041210006900153260000800222300001200230490000800242520130300250100002001553700002001573856012401593       2018                        eng d00aEffect of membrane composition on receptor association: implications of cancer lipidomics on ErbB receptors0 aEffect of membrane composition on receptor association implicati  cJAN  a359-3680 v2513 a<p>The association of single transmembrane receptors, such as the ErbB receptors is a key event in initiating cell signaling networks. The interactions between these receptors have been well characterized for both ligand-driven and pre-formed dimers. However, the role of the membrane in modulating association is less well understood and assumes greater importance in light of altered membrane composition in diseased states. Here, we discuss how membrane composition has been observed to induce both structural and dynamic differences in receptor association. Computational studies, especially those using coarse-grain simulations have been successful in predicting the role of the membrane and calculating the related free energy landscapes. Membrane perturbations and differences in lipid chain order, related to the lipophobic effect, have been shown to play a large role in driving membrane protein association. Further, we review lipid compositions reported in diseased conditions and its effect on transmembrane receptor association, focusing on the ErbB growth factor receptor dimers in cancer. Understanding the role of the membrane in receptor association will provide general design principles driving receptor organization, as well as help to identify novel therapeutic strategies.</p>1 aPawar, Aiswarya1 aSengupta, Durba  uhttps://library.ncl.res.in/content/effect-membrane-composition-receptor-association-implications-cancer-lipidomics-erbb