01178nas a2200205   4500008004100000022001400041245009400055210006900149260000900218490000800227520046400235653002500699653002200724653002700746653002000773100002000793700002600813700002400839856010900863       2023                        eng d  a0040-403900aConcise approach for the synthesis of the tetracyclic framework of Lycibarbarines A and B0 aConcise approach for the synthesis of the tetracyclic framework   cMAY 0 v1213 a<p>
	A simple approach for the construction of the tetracyclic spiroketal skeleton of Lycibarbarine A and B has been described. Employing a solvent free condition for epoxide opening with tetrahydroquinoline as a key reaction to couple both the fragments, an oxidation followed by TBAF-mediated silyl deprotection spiroketalization establishes the complete tetracyclic core present in these natural products. (c) 2023 Elsevier Ltd. All rights reserved.</p>
10aChiral pool approach10aD -Glyceraldehyde10aTetracyclic spiroketal10aTotal synthesis1 aShet, Manoj, N.1 aNechooli, Hemanth, K.1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/concise-approach-synthesis-tetracyclic-framework-lycibarbarines-and-b02265nas a2200253   4500008004100000022001400041245009000055210007000145260000900215300000700224490000800231520140700239653001601646653001901662653003001681653003601711653002001747100002601767700002001793700003001813700002201843700002001865856012601885       2025                        eng d  a0974-362600aDesign and synthesis of C-α-D-mannopyranoside linked mesoporous silica nanoparticles0 aDesign and synthesis of CαDmannopyranoside linked mesoporous sil  cMAR   a210 v1373 a<p>
	Mannose functionalized mesoporous silica nanoparticles (MSNs) offer a promising approach for developing more targeted, effective, and safer cancer therapies. For many of the applications, immobilization of carbohydrates like mannose onto MSNs is a crucial aspect, and in most cases, mannose moieties are connected through O-glycosidic linkages that are susceptible to acidic/enzymatic hydrolysis. To generate a stable mannose-functionalized MSN, we designed a novel C(14)-alpha-mannosylated tetradeca-1-yne. The key steps involved in the synthesis of C-mannosylated alkyne are C1-alkynylation of tri-O-acetyl-D-glucal with 1-trimethylsilyl-tetradec-1-yne, followed by stereoselective dihydroxylation and the isomerization of the internal triple bond to a terminal position. This mannose ligand was then immobilized onto azidopropyl-functionalized SBA-15 through the Cu(I)-catalyzed azide-alkyne click (CuAAC) reaction. Various physical techniques such as low-angle powder XRD, N-2 adsorption isotherms (BET), Fourier transform infrared (FTIR), high-resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA) have been employed to characterize this C-mannosyl SBA-15 silica matrix. We evaluated the binding ability of C-mannosyl SBA-15 nanoparticles by using fluorescein-labelled Con-A as a target protein.</p>
10aC-mannoside10aClick reaction10amannose specific proteins10aMesoporous silica nanoparticles10aZipper reaction1 aNechooli, Hemanth, K.1 aRamtenki, Vilas1 aKumar, Chepuri, V. Suneel1 aPrasad, V., B. L.1 aRamana, Chepuri  uhttps://library.ncl.res.in/content/design-and-synthesis-c-%CE%B1-d-mannopyranoside-linked-mesoporous-silica-nanoparticles