02345nas a2200265   4500008004100000022001400041245021600055210006900271260000900340300000800349490000700357520135000364100002101714700002201735700002501757700002201782700002401804700002301828700001701851700003001868700001501898700002601913700001901939856012101958       2026                        eng d  a0343-865100aComparative metabolite profiling and bioactivity evaluation of pneumatophore-derived aspergillus strains from three geographically distinct mangrove ecosystems of india: isolation of a new dahejpyrone derivative0 aComparative metabolite profiling and bioactivity evaluation of p  cJUL   a4640 v833 a<p>
	In the present investigation, we have isolated a pneumatophore derived Aspergillus species, from the mangrove Ecosystem. Th fungus was identified based on macromorphological characteristics and further confirmed by precise molecular identification using the Internal Transcribed Spacer (ITS) region and identified as Aspergillus niger D-5, Aspergillus sp. NIO-01 and Aspergillus stellatus sp. LM-03. These species were explored for their biologically active metabolites and indented as linoleic acid (1), ethyl linoleate (2), terrain (3), butyrolactone (4), and a new metabolite phenethyl oxopyrane (5) characterized by extensive 1D NMR (1H and 13C) and 2D NMR (HSQC, HMBC, and NOESY) analyses, high-resolution mass spectrometry, high-performance liquid chromatography, and single-crystal X-ray crystallography. These species crude extract exhibited excellent antimicrobial activity, and anti-cancerous activities. We first time report, new dahejpyrone (kavapyrone analog, 5) from Aspergillus niger. Aspergillus niger D-5 extract exhibited higher inhibition to Gram positive bacteria and Candida albicans. The isolated molecules from these species need to be characterized to determine their precise biological activities. In conclusion, the land use land cover classes reveal a strong correlation of mangroves with microbial nature.</p>
1 aFulke, Abhay, B.1 aAwashank, Avinash1 aVinodkumar, Ramavath1 aKontham, Ravindar1 aGonnade, Rajesh, G.1 aTripathi, Devavrat1 aDora, Udhaba1 aVamkudoth, Koteswara, Rao1 aKarthi, J.1 aSwain, Gopal, Krushna1 aTilvi, Supriya  uhttps://library.ncl.res.in/content/comparative-metabolite-profiling-and-bioactivity-evaluation-pneumatophore-derived