01424nas a2200181   4500008004100000022001400041245012600055210006900181260000900250300001400259490000700273520073700280100002201017700003201039700002401071700002201095856012501117       2026                        eng d  a1523-706000aOrganocatalytic enantioselective desymmetrization cascade for the construction of functionalized oxabicyclo[3.3.1]nonanes0 aOrganocatalytic enantioselective desymmetrization cascade for th  cJUL   a8271-82770 v283 a<p>
	The construction of stereochemically enriched molecules from readily accessible meso and prochiral precursors via catalytic enantioselective desymmetrization represents a powerful synthetic strategy. Herein, we report an efficient enantioselective Michael/oxa-Michael cascade reaction between C4-functionalized meso-2,5-cyclohexadienones and beta-ketoesters, catalyzed by a Takemoto chiral squaramide. This protocol enables the efficient construction of densely functionalized oxabicyclo[3.3.1]nonane frameworks bearing two or three stereogenic centers, with good to excellent diastereo- and enantioselectivities. Furthermore, the method is amenable to scale-up and offers opportunities for late-stage functionalization.</p>
1 aChavan, Vikas, S.1 aSahoo, Shubhranshu, Shekhar1 aGonnade, Rajesh, G.1 aKontham, Ravindar  uhttps://library.ncl.res.in/content/organocatalytic-enantioselective-desymmetrization-cascade-construction-functionalized