01904nas a2200193   4500008004100000022001400041245013100055210006900186260000800255300001400263490000700277520118000284100002401464700001801488700002301506700002701529700002801556856012601584       2026                        eng d  a0022-326300aPhotolabile-protected triazine-based janus G-C and Triple G-C-T base-coded nucleobases for supramolecular polymer construction0 aPhotolabileprotected triazinebased janus GC and Triple GCT basec  cJUN  a8085-80950 v913 a<p>
	Janus self-assembling systems show unique behavior due to their dual-sided nature, enabling precise control over the assembly patterns and functional properties. Herein, we report the design and synthesis of photolabile-protected triazine-based nucleobase monomers featuring both Janus G-C and triple G-C-T base-coded motifs. These monomers, derived from DDA (G mimic), DAA (C mimic), and ADA (T mimic) arrays, possess polymerizable functionalities and self-complementary triple hydrogen-bonding sites. The O-nitrobenzyl (O-NB) protecting group imparts exceptional stability under both acidic and basic conditions, thereby enabling diverse polymerization conditions. A representative triple G-C-T monomer was polymerized via free-radical polymerization to yield the corresponding protected polymer, which, upon UV-induced deprotection, regenerated active hydrogen-bonding sites and triggered supramolecular self-assembly, as evidenced by enhanced mechanical performance. This study establishes a versatile synthetic platform for constructing nucleobase-derived Janus monomers with orthogonal reactivity and photochemically switchable supramolecular organizations.</p>
1 aGawande, Akshay, J.1 aDavis, Disiya1 aWagh, Mahendra, A.1 aNair, Kiran, Sukumaran1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/photolabile-protected-triazine-based-janus-g-c-and-triple-g-c-t-base-coded-nucleobases