01690nas a2200181   4500008004100000022001400041245010900055210006900164260000800233300001400241490000700255520101900262100002901281700003001310700002301340700002101363856012401384       2026                        eng d  a1477-052000aRongalite-mediated hydride-free chemoselective reduction of the bond of isatin-derived Michael acceptors0 aRongalitemediated hydridefree chemoselective reduction of the bo  cJUN  a5164-51700 v243 a<p>
	A chemoselective and sustainable reduction of the CC bond in isatin-derived Michael acceptors has been achieved using rongalite as an inexpensive hydride-free reductant. The transformation proceeds efficiently in ethanol at room temperature with p-TSA as an additive, without the need for transition metals, external hydrides, visible light, or additional catalysts. Under these mild conditions, a wide range of substrates were converted to the corresponding reduced products in excellent yields, highlighting the broad applicability of the protocol. Mechanistic studies support a rongalite-mediated 1,4-conjugate addition pathway, which accounts for the observed high selectivity. The practicality and sustainability of the method are further validated by gram-scale synthesis. Furthermore, the protocol is compatible with bioactive isatin derivatives and the corresponding products serve as valuable intermediates for downstream transformations, including spirocyclization and dimerization reactions.</p>
1 aChaudhari, Suryakant, S.1 aNichinde, Chandrakant, B.1 aPatil, Baliram, R.1 aKinage, Anil, K.  uhttps://library.ncl.res.in/content/rongalite-mediated-hydride-free-chemoselective-reduction-bond-isatin-derived-michael