00988nas a2200157 4500008004100000245009500041210006900136260000900205300001400214490000700228520039600235100003300631700002000664700002000684856012600704 2026 eng d00aSite-selective iron-catalyzed C-H alkylation of pyrazinones, azauracils and quinoxalinones0 aSiteselective ironcatalyzed CH alkylation of pyrazinones azaurac cMAY  a2725-27290 v133 a

Described herein is an unprecedented iron-catalyzed C(sp2)-H alkylation of pyrazinone, azauracil, and quinoxalinone analogues using ethers and benzyl derivatives, offering broad scope and high functional group tolerance. The method is scalable and enables downstream functionalization. The mechanistic investigations, such as radical trapping, support a radical-mediated pathway.

1 aPansare, Vaibhav, Ramchandra1 aSreelakshmi, N.1 aBarsu, Nagaraju uhttps://library.ncl.res.in/content/site-selective-iron-catalyzed-c-h-alkylation-pyrazinones-azauracils-and-quinoxalinones