01455nas a2200181   4500008004100000022001400041245013700055210006900192260000800261300001400269490000700283520076600290100002501056700002001081700002401101700002201125856012601147       2026                        eng d  a0022-326300aDivergent synthesis of meyers' lactams and medium lactams via cyclocondensation of γ-ylidene-butanolides with chiral amino alcohols0 aDivergent synthesis of meyers lactams and medium lactams via cyc  cAPR  a5138-51580 v913 a<p>
	A novel methodology for constructing Meyers' lactams (pyrrolidino-oxazolidines), related to biologically potent natural and synthetic scaffolds, has been developed via an unprecedented tandem cyclocondensation of chiral 2-amino alcohols and gamma-ylidene-butanolides. The process proceeds through the initial formation of an ene-lactam intermediate, followed by a Bro/nsted acid (PPTS)-catalyzed ring closure. Under stoichiometric amounts of a Lewis acid (TiCl4), the same set of building blocks affords medium lactams featuring eight-membered ring systems with an exo-enol ether segment. This divergent synthetic strategy enables the efficient generation of a library of Meyers' lactams and medium lactams with good yields and diastereoselectivity.</p>
1 aSadanande, Megha, V.1 aSharma, Paridhi1 aGonnade, Rajesh, G.1 aKontham, Ravindar  uhttps://library.ncl.res.in/content/divergent-synthesis-meyers-lactams-and-medium-lactams-cyclocondensation-%CE%B3-ylidene