01460nas a2200181   4500008004100000245010600041210006900147260000900216300001400225490000700239520077400246100002301020700003001043700002801073700002901101700002101130856012701151       2026                        eng d00aThiophenol-mediated metal-free chemoselective conjugate reduction strategy for 3-alkylidene oxindoles0 aThiophenolmediated metalfree chemoselective conjugate reduction   cFEB   a7702-77060 v163 a<p>
	A mild and metal-free thiophenol-mediated chemoselective conjugate reduction of 3-alkylidene oxindoles via a thiol-ene-type Michael addition was effectively carried out. Thiophenol as an efficient reductant is used in DMSO, and the transformation proceeds without the need for metal catalyst, external hydrogen source, or harsh reagents. The reaction displays a broad substrate scope, accommodating both electron-donating and electron-withdrawing substituents, and delivers 3-alkyloxindoles in high yields with excellent beta-selectivity. This sustainable and operationally simple method unveils a distinct thiol-mediated reduction mechanism, providing a green and versatile approach for accessing reduced oxindole derivatives and related Michael acceptors.</p>
1 aPatil, Baliram, R.1 aNichinde, Chandrakant, B.1 aGirase, Amardipsing, S.1 aChaudhari, Suryakant, S.1 aKinage, Anil, K.  uhttps://library.ncl.res.in/content/thiophenol-mediated-metal-free-chemoselective-conjugate-reduction-strategy-3-alkylidene