01159nas a2200193 4500008004100000022001400041245013500055210006900190260000800259300001400267490000700281520046000288100001700748700001900765700002600784700001700810700001500827856012300842 2025 eng d a1523-706000aPalladium(II)-catalyzed desymmetrization of 2-alkynylbenzoate-tethered cyclohexadienones for the synthesis of polycyclic compounds0 aPalladiumIIcatalyzed desymmetrization of 2alkynylbenzoatetethere cMAY a5429-54340 v273 a

Pd-catalyzed cascade cyclization of 2-alkynylbenzoate-tethered cyclohexadienone was developed for the single step synthesis of isocoumarin-fused dihydrochromenones. This highly atom economical method proceeds via 6-endo-dig cyclization of tert-butyl benzoate with a tethered alkyne. By modulating the reaction solvent and metal catalyst, the methodology was diverted for the purposeful synthesis of either of the E/Z tetra-substituted alkenes.

1 aRai, Archana1 aBajpai, Priyam1 aGamidi, Rama, Krishna1 aVanka, Kumar1 aDas, Utpal uhttps://library.ncl.res.in/content/palladiumii-catalyzed-desymmetrization-2-alkynylbenzoate-tethered-cyclohexadienones