01377nas a2200169   4500008004100000022001400041245018000055210006900235260000900304300001400313490000700327520066700334100002801001700002401029700002401053856013001077       2025                        eng d  a1523-706000aDiastereoselective synthesis of cyclic and spirocyclic quaternary carbons via iron-catalyzed ring contraction of cyclic ketones: a formal synthesis of perhydrohistrionicotoxin0 aDiastereoselective synthesis of cyclic and spirocyclic quaternar  cAUG   a8798-88030 v273 a<p>
	The iron-catalyzed hydrogen atom transfer (HAT)-initiated Dowd-Beckwith rearrangement presents a new approach for synthesizing cyclic and spirocyclic quaternary carbons from readily available beta-keto esters and cyclic diketones with high yields. This reaction proceeds in a stereocontrolled manner, enabling the formation of synthetically valuable cyclic ketones with two contiguous stereocenters, including quaternary centers. This transformation introduces an innovative bond disconnection strategy for ring-contraction reactions. Additionally, a short formal synthesis of perhydrohistrionicotoxin was efficiently achieved using this methodology.</p>
1 aSurvase, Vijayanand, U.1 aRokade, Avinash, D.1 aHandore, Kishor, L.  uhttps://library.ncl.res.in/content/diastereoselective-synthesis-cyclic-and-spirocyclic-quaternary-carbons-iron-catalyzed-ring