01579nas a2200205   4500008004100000022001400041245010000055210006900155260000800224490000700232520086900239653001101108653002901119653001701148653002401165653001601189100002001205700002001225856012801245       2025                        eng d  a1861-472800aCoBr2-catalyzed straightforward synthesis of quinoxalines via dehydrogenative coupling strategy0 aCoBr2catalyzed straightforward synthesis of quinoxalines via deh  cDEC0 v203 a<p>
	Establishing a benign and straightforward protocol for synthesizing biorelevant and synthetically valuable quinoxaline is very important. Herein, we report a simple and efficient protocol for the sustainable synthesis of diverse quinoxaline derivatives catalyzed by cobalt salt. The reaction proceeds through the dehydrogenative coupling of alkyl and aryl ethane 1,2-diols with aryl diamines in the presence of a catalytic CoBr2/K2CO3. The usage of the greener solvent 2-MeTHF and the release of H2 and H2O as the sole byproducts make the process advantageous. The protocol led to the synthesis of diverse quinoxalines bearing synthetically useful functionalities, such as fluoro, chloro, bromo, cyano, trifluoromethyl, and ether. The reaction is presumed to proceed via the dehydrogenative-condensation pathway involving a cobalt-hydride intermediate.</p>
10acobalt10adehydrogenative coupling10aheterocycles10aligand-free process10aQuinoxaline1 aDubey, Shivansh1 aPunji, Benudhar  uhttps://library.ncl.res.in/content/cobr2-catalyzed-straightforward-synthesis-quinoxalines-dehydrogenative-coupling-strategy