01621nas a2200205   4500008004100000022001400041245007700055210006900132260000800201300001600209490000700225520095300232100001901185700001601204700002501220700002401245700001701269700001901286856011001305       2025                        eng d  a0020-166900aMagnesium-catalyzed primary, secondary, and tertiary amide hydroboration0 aMagnesiumcatalyzed primary secondary and tertiary amide hydrobor  cJUN  a13405-134140 v643 a<p>
	Catalytic hydroboration of amides is highly important because the resultant amines are commonly found in natural products, pharmaceuticals, agrochemicals, dyes, and other applications. In comparison to the conventional reduction of amides using (over)stoichiometric reductants, hydroboration of amides using magnesium compounds represents a green and sustainable approach because magnesium is both Earth abundant and environmentally benign. However, there is only one report on magnesium-catalyzed deoxygenative hydroboration of secondary and tertiary amides. Here, we describe the synthesis and structural authentication of two new magnesium compounds (1 and 2) featuring a flexible PNP ligand and the utilization of 2 as a catalyst for the pinacolborane-mediated reduction of primary, secondary, and tertiary amides to amines. The reaction scope is explored, and a mechanism is proposed based on experimental and theoretical insights.</p>
1 aMahata, Biplab1 aDevaraj, V.1 aDash, Soumya, Ranjan1 aGonnade, Rajesh, G.1 aVanka, Kumar1 aSen, Sakya, S.  uhttps://library.ncl.res.in/content/magnesium-catalyzed-primary-secondary-and-tertiary-amide-hydroboration