02081nas a2200205   4500008004100000245009500041210006900136260000800205300000900213490000700222520140100229100001701630700001601647700002001663700001501683700001801698700001901716700001801735856012201753       2024                        eng d00aFeedback driven autonomous cycles of assembly and disassembly from minimal building blocks0 aFeedback driven autonomous cycles of assembly and disassembly fr  cNOV  a99800 v153 a<p>
	The construction of complex systems by simple chemicals that can display emergent network dynamics might contribute to our understanding of complex behavior from simple organic reactions. Here we design single amino acid/dipeptide-based systems that exhibit multiple periodic changes of (dis)assembly under non-equilibrium conditions in closed system, importantly in the absence of evolved biocatalysts. The two-component based building block exploits pH driven non-covalent assembly and time-delayed accelerated catalysis from self-assembled state to install orthogonal feedback loops with a single batch of reactants. Mathematical modelling of the reaction network establishes that the oscillations are transient for this network structure and helps to predict the relative contribution of the feedback loop to the ability of the system to exhibit such transient oscillation. Such autonomous systems with purely synthetic molecules are the starting point that can enable the design of active materials with emergent properties. The study of the network dynamics of complex systems formed by simple chemicals can contribute to our understanding of complex behavior from simple organic reactions. Here, built on the minimal building blocks, the authors describe a system with periodic (dis)assembly utilizing feedback loops controlled by time-delayed catalysis and pH-driven assembly.</p>
1 aReja, Antara1 aJha, Sangam1 aSreejan, Ashley1 aPal, Sumit1 aBal, Subhajit1 aGadgil, Chetan1 aDas, Dibyendu  uhttps://library.ncl.res.in/content/feedback-driven-autonomous-cycles-assembly-and-disassembly-minimal-building-blocks