01410nas a2200181   4500008004100000245015700041210007100198260000800269300001400277490000700291520066600298100002300964700003000987700002901017700002601046700002101072856013501093       2024                        eng d00aOrganocatalyzed [4+2] cycloaddition of α,β-unsaturated ketones and isatylidene malononitrile: accessing spiro[3-arylcyclohexanone]oxindole derivatives0 aOrganocatalyzed 42 cycloaddition of αβunsaturated ketones and is  cJAN  a2873-28770 v143 a<p>
	Herein, we developed a series of compounds featuring spiro[3-arylcyclohexanone]oxindoles through Barbas [4 + 2] cycloaddition reactions between isatylidene malononitrile and alpha,beta-unsaturated ketones using l-proline as an organocatalyst. The reported methodology offers many advantages such as mild reaction conditions, diverse substrate scope with high yields, easy reaction setup, and use of easily synthesizable starting materials. An l-proline catalyzed-Barbas-[4 + 2]-cycloaddition reaction is reported for the synthesis of spiro[3-arylcyclohexanone]oxindole derivatives. The method can tolerate a diverse substrate scope with high yields.</p>
1 aPatil, Baliram, R.1 aNichinde, Chandrakant, B.1 aChaudhari, Suryakant, S.1 aKrishna, Gamidi, Rama1 aKinage, Anil, K.  uhttps://library.ncl.res.in/content/organocatalyzed-42-cycloaddition-%CE%B1%CE%B2-unsaturated-ketones-and-isatylidene-malononitrile