03149nas a2200229 4500008004100000245010900041210006900150260000800219300001200227490000700239520235000246100002702596700001602623700002302639700001902662700001902681700001702700700002102717700002602738700002502764856013002789 2024 eng d00aYoga therapy attenuates the progression of diabetes - insights from proteomics and metabolomics analysis0 aYoga therapy attenuates the progression of diabetes insights fro cDEC a163-1740 v173 a

Objective: Diabetes management remains challenging despite advancements in therapeutics, with many subjects developing complications. Yoga has been shown to aid diabetes management. This study investigates the impact of yoga therapy on diabetes progression, utilizing proteomics and metabolomics analyses to explore underlying molecular mechanisms.

Methodology: A 3-month longitudinal study involving healthy subjects with prediabetes and diabetes was conducted. Blood glucose, glycated hemoglobin (HbA1c), lipid profile, and malondialdehyde (MDA) levels were measured before and after the yoga intervention.

Results and conclusion: Healthy subjects showed no significant changes in blood glucose, lipid profile, HbA1c, or MDA levels. However, subjects with prediabetes and diabetes experienced positive changes, with decreases in HbA1c and MDA levels. Proteomics and metabolomics analyses provided insights into the molecular mechanisms by which yoga attenuates diabetes progression in subjects with prediabetes and diabetes. This study is a pioneering effort to understand the molecular basis of yoga's beneficial effects on diabetes management.

1 aSonwane, Babasaheb, P.1 aRaut, Pooja1 aChitalkar, Jyotsna1 aGodbole, Smita1 aSabnis, Shanta1 aGupta, Jyoti1 aSanthakumari, B.1 aDeshpande, Mukund, V.1 aKulkarni, Mahesh, J. uhttps://library.ncl.res.in/content/yoga-therapy-attenuates-progression-diabetes-insights-proteomics-and-metabolomics-analysis