02471nas a2200277   4500008004100000022001400041245014400055210006900199260000800268300001200276490000700288520152400295653001001819653001101829653003801840653001701878653002101895653002501916653001101941653002101952653003001973100001702003700002202020700002802042856012302070       2025                        eng d  a1022-552800aUltra-small Pd nanoparticles on SBA-15: an efficient catalyst for one-pot reductive alkylation of nitrobenzene with size-dependent activity0 aUltrasmall Pd nanoparticles on SBA15 an efficient catalyst for o  cFEB  a414-4290 v683 a<p>
	One-pot reductive alkylation of nitrobenzene with alcohol is an important organic synthesis reaction to form 2 degrees amines. In the present work, we have demonstrated that Pd/SBA-15 can be an effective catalytic system for this reaction. We have designed ultra-small Pd nanoparticles supported on SBA-15 for the synthesis of secondary amine, N-ethylaniline, through one-pot reductive alkylation of nitrobenzene with ethanol under ambient conditions. Ethanol functions both as the alkylating agent and the solvent in this process. The reaction is driven by the simultaneous hydrogenation of nitrobenzene to aniline, dehydrogenation of ethanol to aldehyde, and condensation of aniline and acetaldehyde to form N-ethylaniline. The size of the Pd nanoparticles plays a decisive role in the product selectivity. The undercoordinated sites present on ultra-small Pd NPs can facilitate ethanol dehydrogenation to acetaldehyde, thereby enhancing the selectivity towards N-ethylaniline compared to larger Pd nanoparticles. We have also studied the effect of different mesoporous supports such as SBA-15, MCM-41, and KIT-6 on the N-ethylaniline selectivity and found that SBA-15 was most selective. We have demonstrated that by carefully designing the catalyst such as controlling the Pd NPs size to obtain the maximum quantity of undercoordinated sites and choosing suitable support, the aliphatic alcohols can also be used for reductive alkylation of nitrobenzene in one-pot with optimum yields of N-alkylaniline.</p>
10aKIT-610aMCM-4110aModified deposition precipitation10anitrobenzene10aPd nanoparticles10aReductive alkylation10aSBA-1510asecondary amines10aUndercoordinated Pd sites1 aSoni, Yogita1 aPhilip, Milda, C.1 aVinod, Chathakudath, P.  uhttps://library.ncl.res.in/content/ultra-small-pd-nanoparticles-sba-15-efficient-catalyst-one-pot-reductive-alkylation