01096nas a2200181 4500008004100000022001400041245017100055210006900226260000900295300001200304490000700316520036400323100002500687700002400712700002600736700002200762856013000784 2025 eng d a1359-734500aAgOTf-catalyzed cascade annulation of 5-hexyn-1-ols and aldehydes: enabling the diastereoselective synthesis of [6,6,6]-trioxa-fused ketals and hexahydro-2H-chromenes0 aAgOTfcatalyzed cascade annulation of 5hexyn1ols and aldehydes en cJAN  a973-9760 v613 a

We report the unprecedented diastereoselective synthesis of novel [6,6,6]-trioxa-fused ketals via AgOTf-catalyzed cascade annulation of 5-hexyn-1-ols (with primary or secondary hydroxyl groups) and aldehydes through a [2+2+1+1] pathway. In contrast, 5-hexyn-1-ols with tertiary hydroxyl groups yield hexahydro-2H-chromenes via a [3+1+1+1] pathway.

1 aVinodkumar, Ramavath1 aNakate, Ashwini, K.1 aKrishna, Gamidi, Rama1 aKontham, Ravindar uhttps://library.ncl.res.in/content/agotf-catalyzed-cascade-annulation-5-hexyn-1-ols-and-aldehydes-enabling-diastereoselective