01309nas a2200253 4500008004100000022001400041245010400055210006900159260000800228300001500236490000700251520048200258653000600740653002500746653001500771653002000786653001900806653001700825653001800842100002100860700002100881700002200902856013100924 2025 eng d a2365-654900aIron mediated oxidative ring opening-homocoupling of cyclopropanols: facile access to 1,6-diketones0 aIron mediated oxidative ring openinghomocoupling of cyclopropano cMAY ae2025017450 v103 a

We have developed a new approach for the synthesis of 1,6-diketones via iron-catalyzed ring opening of cyclopropanol with a nontoxic, inexpensive iron catalyst under open-air conditions. This method eliminates the need for additives and employs tert-butanol as an eco-friendly solvent. This methodology allows rapid access to a variety of symmetrical 1,6-diketones under mild conditions. Preliminary mechanistic studies revealed the involvement of radical pathways.

10a110a6-Diketone synthesis10aC & horbar10aC bond cleavage10acyclopropanols10aHomocoupling10aIron mediated1 aShinde, Ravi, A.1 aShirsath, Sachin1 aMuthukrishnan, M. uhttps://library.ncl.res.in/content/iron-mediated-oxidative-ring-opening-homocoupling-cyclopropanols-facile-access-16-diketones