02862nas a2200205 4500008004100000245017400041210006900215260000800284300001200292490000700304520205400311100001702365700002502382700001902407700002502426700002202451700002802473700002402501856013102525 2024 eng d00aBlock copolymer self-assembly: exploitation of hydrogen bonding for nanoparticle morphology control via incorporation of triazine based comonomers by RAFT polymerization0 aBlock copolymer selfassembly exploitation of hydrogen bonding fo cOCT a24011290 v203 a

Synthesis of polymeric nanoparticles of controlled non-spherical morphology is of profound interest for a wide variety of potential applications. Self-assembly of amphiphilic diblock copolymers is an attractive bottom-up approach to prepare such nanoparticles. In the present work, RAFT polymerization is employed to synthesize a variety of poly(N,N-dimethylacrylamide)-b-poly[butyl acrylate-stat-GCB] copolymers, where GCB represents vinyl monomer containing triazine based Janus guanine-cytosine nucleobase motifs featuring multiple hydrogen bonding arrays. Hydrogen bonding between the hydrophobic blocks exert significant influence on the morphology of the resulting nanoparticles self-assembled in water. The Janus feature of the GCB moieties makes it possible to use a single polymer type in self-assembly, unlike previous work exploiting, e.g., thymine-containing polymer and adenine-containing polymer. Moreover, the strength of the hydrogen bonding interactions enables use of a low molar fraction of GCB units, thereby rendering it possible to use the present approach for copolymers based on common vinyl monomers for the development of advanced nanomaterials.

1 aHaque, Farah1 aThompson, Steven, W.1 aIshizuka, Fumi1 aKuchel, Rhiannon, P.1 aSingh, Dharmendra1 aSanjayan, Gangadhar, J.1 aZetterlund, Per, B. uhttps://library.ncl.res.in/content/block-copolymer-self-assembly-exploitation-hydrogen-bonding-nanoparticle-morphology-control