01527nas a2200181   4500008004100000022001400041245012400055210006900179260000900248300001400257490000700271520084800278100001701126700002001143700002401163700002601187856013201213       2024                        eng d  a1359-734500a2,3-Difunctionalization of quinones: a gold-catalyzed cascade approach for trifluoromethyl-amination or sulfoximination0 a23Difunctionalization of quinones a goldcatalyzed cascade approa  cAUG   a9598-96010 v603 a<p>
	A one-pot domino protocol employing gold(i) catalysis has been developed for the cascade trifluoromethyl-amination/sulfoximination of quinones. Togni I serves as the trifluoromethyl installing precursor, while amine or sulfoximine serves as the aminating source. Preliminary investigations suggest a mutual activation of Togni I and the amine precursor, facilitating the facile difunctionalization of quinones with excellent regioselectivity. Extensive substrate scope exploration demonstrates moderate to good yields of difunctionalized products. Application to the natural product Juglone highlights its potential for late-stage modifications in medicinal chemistry and drug discovery. A one-pot domino protocol employing gold(i) catalysis has been developed for the cascade trifluoromethyl-amination/sulfoximination of quinones.</p>
1 aSharma, Alpa1 aGovande, Vijaya1 aMahajan, Shivangani1 aSawant, Sanghapal, D.  uhttps://library.ncl.res.in/content/23-difunctionalization-quinones-gold-catalyzed-cascade-approach-trifluoromethyl-amination-or