00980nas a2200157 4500008004100000022001400041245007100055210006900126260000900195300001200204490000700216520044300223100003300666700002000699856010300719 2025 eng d a1477-052000aBase-mediated denitrative C3-alkylation of quinoxaline derivatives0 aBasemediated denitrative C3alkylation of quinoxaline derivatives cJAN  a303-3070 v233 a

We have developed a novel base-mediated method for the selective C3-alkylation of quinoxalin-2(1H)-one and N-protected quinoxalin-2(1H)-one using inexpensive, unactivated nitroalkanes. This approach tolerates a wide range of functional groups and supports the synthesis of various bioactive compounds. Gram-scale reactions demonstrate the scalability of the method. The proposed mechanism was validated by control experiments.

1 aPansare, Vaibhav, Ramachandr1 aBarsu, Nagaraju uhttps://library.ncl.res.in/content/base-mediated-denitrative-c3-alkylation-quinoxaline-derivatives