01264nas a2200157   4500008004100000245010600041210006900147260000800216300001400224490000700238520066800245100002000913700002200933700002600955856012500981       2024                        eng d00aStructural basis for a two-dimensional flexible pharmaceutical solvate crystal: indomethacin methanol0 aStructural basis for a twodimensional flexible pharmaceutical so  cOCT  a5694-56980 v263 a<p>
	We report the first two-dimensionally (2D) elastically bendable and twistable pharmaceutical-solvate crystal, indomethacin methanol. Its flexibility is due to interlocked packing and a structural buffer acting like isotropic interactions. For the first time, we utilized Raman spectroscopy on the two elastic faces of a bent crystal region, revealing the inhomogeneous molecular distribution in the crystal structure during bending and validating the mechanistic model of the 2D elastic crystal. We present the first 2D elastic pharmaceutical-solvate crystal and utilized Raman spectroscopy to reveal inhomogeneous lattice distribution during bending.</p>
1 aBhowmik, Aritra1 aBamane, Sanjivani1 aMishra, Manish, Kumar  uhttps://library.ncl.res.in/content/structural-basis-two-dimensional-flexible-pharmaceutical-solvate-crystal-indomethacin