01750nas a2200229   4500008004100000022001400041245009200055210006900147260000800216300001500224490000600239520100200245653001501247653001401262653001601276653001101292653002601303100002401329700001901353700002801372856012001400       2024                        eng d  a2365-654900aStrategies employing transition-metal free conditions for C-C bond formation in indoles0 aStrategies employing transitionmetal free conditions for CC bond  cSEP  ae2024032800 v93 a<p>
	Indole motifs are omnipresent in nature and can be found in many natural products as well as pharmaceuticals. It is for this reason synthetic transformations of indole have become a topic of interest for the organic and medicinal chemist community for decades. In this review, we have emphasized the functionalization of indoles via transition-metal-free approaches. This review touches on many aspects in different sub-sections, which gives a proposition of the tactics employed for the functionalization of indoles and an overview of the road ahead. In this review, essentially transition-metal-free conditions for C-C bond formation reactions in indoles has been explored. This review describes various approaches of functionalization at the C-2, C-3, C-4 and C-7 position of indoles which comprises arylation, alkenylation, acylation, formylation, alkylation, bisindolyl and cyclization strategies. Also, strategies incorporating N-alkylation/arylation has also been covered. image</p>
10aAlkylation10aArylation10aformylation10aIndole10atransition-metal free1 aGhodake, Balaji, M.1 aPaul, Sayantan1 aBhattacharya, Asish, K.  uhttps://library.ncl.res.in/content/strategies-employing-transition-metal-free-conditions-c-c-bond-formation-indoles