01403nas a2200157   4500008004100000022001400041245020000055210006900255260000800324300001400332490000700346520071100353100003101064700002601095856012401121       2024                        eng d  a1523-706000aIntegrating 3,4-Dihydro-2H-1,4-oxazine into peptides as a modification: silver triflate-catalyzed cyclization of N-Propargyl N-Sulfonyl amino alcohols for SPPS applications                       0 aIntegrating 34Dihydro2H14oxazine into peptides as a modification  cSEP  a7584-75890 v263 a<p>
	We present a methodology yielding 3,4-dihydro-2H-1,4-oxazine by cyclization of N-propargyl N-sulfonyl amino alcohols using silver triflate as a catalyst at ambient temperature. Additionally, we showcase the applicability of this methodology in solid phase peptide synthesis (SPPS) to introduce the oxazine heterocyclic ring into short peptides containing serine and threonine. Notably, Rink amide resin supported the on-resin formation of 3,4-dihydro-2H-1,4-oxazine, while 2-CTC resin facilitated the oxazine formation in a one-pot process involving peptide cleavage, deprotection, and subsequent C-O ring formation, thus offering a versatile method for the late-stage modification of peptides.</p>
1 aPatil, Abhijit, Ramchandra1 aMarelli, Udaya, Kiran  uhttps://library.ncl.res.in/content/integrating-34-dihydro-2h-14-oxazine-peptides-modification-silver-triflate-catalyzed