01201nas a2200205 4500008004100000022001400041245014000055210006900195260000800264300001400272490000700286520043800293653001800731653002800749653001500777653002100792100002600813700002600839856013000865 2023 eng d a1478-641900aEnantioselective synthesis of (+)-Sedridine, (-)-Allosedridine and their N-Methyl analogs via Maruoka-Keck allylation and CBS reduction0 aEnantioselective synthesis of Sedridine Allosedridine and their  cOCT a3388-33940 v373 a

A simple synthetic approach has been developed for the enantioselective total synthesis of (+)-Sedridine, (-)-Allosedridine and their analogs such as (+)-N- Methyl Sedridine and (-)-N-Methylallosedridine. The synthesis was achieved by using commercially available starting materials via Maruoka-Keck allylation, Wacker oxidation, and CBS reduction. The synthetic root provides a good diastereomeric ratio and high yields.

10aCBS reduction10aMaruoka-Keck allylation10aPiperidine10aWacker oxidation1 aBhoite, Shubhangi, P.1 aSuryavanshi, Gurunath uhttps://library.ncl.res.in/content/enantioselective-synthesis-sedridine-allosedridine-and-their-n-methyl-analogs-maruoka-keck