01956nas a2200241   4500008004100000022001400041245018500055210007000240260000900310490000600319520103700325653002901362653003401391653001401425653002801439653002101467100001701488700001701505700002201522700001801544700001601562856013601578       2024                        eng d  a2365-654900aN-SO3H functionalised brønsted acidic ionic liquid catalysed sequential one-pot synthesis of 2-amino-3-cyanopyridines via claisen-schmidt condensation under solvent-free condition0 aNSO3H functionalised brønsted acidic ionic liquid catalysed sequ  cMAR 0 v93 a<p>
	This work presents a simple approach for the synthesis of 2-amino-3-cyanopyridines via a one pot two-step sequential route catalysed by direct N–SO3H functionalised Br &amp; oslash;nsted acidic ionic liquids (BAILs). Herein, catalytic activities of four BAILs namely ([TSPi][Cl](2), [DSIM][TFA], [EDSIM][TFA] and [DBDSA][TFA]) were explored and among them [TSPi][Cl](2) was found to be the most efficient reusable homogeneous catalyst. This process involves the ionic liquid catalysed in situ generation of chalcones from Claisen-Schmidt condensation between aromatic aldehydes and acetophenone/4-Cl acetophenone, followed by multicomponent reaction (MCR) with malononitrile and ammonium acetate using the same IL catalyst to selectively produce 2-amino-3-cyanopyridine derivatives in a solvent-free medium at 80 degrees C within 30-60 minutes in high yields (96-86 %). This amalgamation of MCR with ionic liquids and solvent-free conditions makes the present work more compliant with the protocols of Green Chemistry.</p>
10a2-amino-3-cyanopyridines10aBronsted acidic ionic liquids10achalcones10aMulticomponent reaction10aOne-pot approach1 aDas, Sukanya1 aPaul, Subham1 aKashyap, Niharika1 aSaikia, Pinku1 aBorah, Ruli  uhttps://library.ncl.res.in/content/n-so3h-functionalised-br%C3%B8nsted-acidic-ionic-liquid-catalysed-sequential-one-pot-synthesis-2