01810nas a2200205   4500008004100000022001400041245012800055210006900183260000800252300001400260490000700274520103600281100002901317700003001346700002301376700002801399700002601427700002101453856013001474       2024                        eng d  a1477-052000aBase controlled rongalite-mediated reductive aldol/cyclization and dimerization of isatylidene malononitriles/cyanoacetates0 aBase controlled rongalitemediated reductive aldolcyclization and  cFEB  a1727-17320 v223 a<p>
	In this study, we developed a novel methodology involving a base-controlled, rongalite-mediated reductive/aldol reaction, followed by cyclization of isatylidene malononitriles/cyanoacetates, resulting in the synthesis of spiro[2,3-dihydrofuran-3,3 `-oxindole]. Additionally, we have disclosed a rongalite-mediated dimerization process for isatylidene malononitriles, yielding dispiro[cyclopent-3 `-ene]bisoxindole. The utilization of rongalite in this reaction serves a dual purpose, acting both as a reducing agent and a C1 synthon. The developed approach has several advantages like a simple reaction setup, a wide substrate scope, requiring less time, using water as a green solvent, no metal or catalyst is required and products can be easily isolated via filtration with excellent yields under mild reaction conditions. A novel methodology was developed for the synthesis of spiro[2,3-dihydrofuran-3,3 `-oxindole] and dispiro[cyclopent-3 `-ene]bisoxindole under mild reaction conditions using inexpensive reagents.</p>
1 aChaudhari, Suryakant, S.1 aNichinde, Chandrakant, B.1 aPatil, Baliram, R.1 aGirase, Amardipsing, S.1 aKrishna, Gamidi, Rama1 aKinage, Anil, K.  uhttps://library.ncl.res.in/content/base-controlled-rongalite-mediated-reductive-aldolcyclization-and-dimerization-isatylidene