01258nas a2200169   4500008004100000022001400041245014400055210006900199260000900268300001400277490000700291520058000298100002300878700002600901700002600927856013500953       2024                        eng d  a0022-326300aMetal-free one-pot domino synthesis of oxazolidinethione derivatives of quaternary amino acids from α-amino esters and aldehydes using CS20 aMetalfree onepot domino synthesis of oxazolidinethione derivativ  cFEB   a7109-71140 v893 a<p>
	We present a streamlined, metal-free, one-pot domino approach to efficiently synthesize oxazolidinethione derivatives containing substituted quaternary amino acids. This method employs alpha-amino esters, aldehydes, and CS2 under mild conditions, constructing three new bonds (C-N, C-C, and C-O) to produce oxazolidinethione compounds featuring a quaternary center and a beta-hydroxy derivative in high yields. This scalable protocol enables the creation of libraries of biologically significant, intricate amino acid derivatives using amino esters and aldehydes.</p>
1 aShinde, Dinesh, R.1 aKrishna, Gamidi, Rama1 aMarelli, Udaya, Kiran  uhttps://library.ncl.res.in/content/metal-free-one-pot-domino-synthesis-oxazolidinethione-derivatives-quaternary-amino-acids-%CE%B1