01989nas a2200205   4500008004100000022001400041245017100055210006900226260000800295300001400303490000700317520119400324100002601518700002801544700002401572700001501596700001701611700002501628856013001653       2024                        eng d  a2044-475300aNickel-catalyzed tandem conversion of paraformaldehyde : methanol to hydrogen and formate/chemo- and stereoselective hydrogenation of alkynes under neutral conditions0 aNickelcatalyzed tandem conversion of paraformaldehyde methanol t  cMAY  a2779-27930 v143 a<p>
	The development of new catalytic protocols for clean and COx-free hydrogen generation from fundamental feedstocks is always interesting and challenging. Herein, we disclose nickel-catalyzed dihydrogen generation from a mixture of paraformaldehyde-methanol under base-free and activator-free conditions. The dihydrogen generation from this redox combination under neutral, oxidative coupling conditions has been integrated with the hydrogen transfer reactions such as chemo- and stereoselective hydrogenation of alkynes in a tandem manner. This unprecedented strategy provides diverse highly stereoselective olefins with excellent tolerance of reducible functional groups such as ether, silyl ether, aldehyde, keto, ester, nitrile, halides including bromo and iodo groups, and heteroarenes. Additionally, we demonstrated catalytic stereo-interconversion of alkenes under benign conditions. The affordable gram-scale synthesis of some important pharmaceutical bioactive molecules has further enhanced their synthetic value. A tandem dihydrogen generation from a mixture of paraformaldehyde-methanol under base-free conditions followed by semihydrogenation of alkynes is reported.</p>
1 aSubaramanian, Murugan1 aPadhy, Subarna, Sukanya1 aGouda, Chandrakanth1 aDas, Tamal1 aVanka, Kumar1 aBalaraman, Ekambaram  uhttps://library.ncl.res.in/content/nickel-catalyzed-tandem-conversion-paraformaldehyde-methanol-hydrogen-and-formatechemo-and