01921nas a2200205   4500008004100000022001400041245015100055210006900206260000800275490000800283520112400291653001801415653002701433653001301460653002801473653003301501100002801534700002301562856013001585       2024                        eng d  a0926-669000aReview on microbial 1, 3-propanediol production: Emerging strategies, key hurdles and attainable solutions to re-establish its commercial interest0 aReview on microbial 1 3propanediol production Emerging strategie  cMAR0 v2093 a<p>1,3-propanediol (1,3-PDO) is a vital value-added bi-functional compound that has numerous uses in the industrial sector including the polymer, pharmaceutical, food, and cosmetics industries. 1,3-PDO biosynthesis from renewable resources through green methods has received considerable attention. However, technical difficulties such as low product titer, by-product accumulation, and incomplete substrate consumption impede its sustainable production at the industrial scale. Hence, understanding the overall 1,3-PDO process development with integrated knowledge of techno-economics would help to build more production facilities across the world. In this view, the biotechnological production of 1,3-PDO is systematically reviewed briefing the synthesis routes, microbial strains, metabolic pathways, and fermentation modes along with several purification strategies. The present review also summarizes key hurdles in 1,3-PDO production and discusses the attainable solutions to achieve higher product titer. Finally, the economic viability of 1,3-PDO biosynthesis is described based on the existing research.</p>
10a3-Propanediol10aFermentation processes10aGlycerol10aPurification strategies10aTechno-economical assessment1 aNimbalkar, Pranhita, R.1 aDharne, Mahesh, S.  uhttps://library.ncl.res.in/content/review-microbial-1-3-propanediol-production-emerging-strategies-key-hurdles-and-attainable